Bioelectronics

Collectively, the evidence supports a coherent scientific rationale for the application of exogenous EST to chronic hard-to-heal wounds.10 Indeed, significant clinical evidence for the beneficial effects of EST on chronic wounds has now accumulated11-13 across a range of different EST devices.

Amongst 40 hard-to-heal wounds recruited from three international sites, 78% of wounds displayed marked reductions in peri-wound oedema, inflammation, wound depth and area, that had not been seen during the preceding weeks of care in the same institutions. In these wounds, the clinical signs suggest the physiology of the wound had changed and that reparative process were in motion.

We demonstrated the working principle of this concept using culture models of skin wounds, and showed that EF guidance cues can increase the wound closure speed up to 3×, in comparison to non-stimulated controls.

Micro-Z™ technology is an effective therapy for

• Muscle re-education and muscle strengthening

• Improving wound healing & increasing closure of wounds

• Improvement of circulation in lower extremities

• Neuropathic pain

• Post-op pain

• Acute and chronic pain

"I am a USMC Vietnam Vet. I have diabetes among other things. With type 2 diabetics I was having neuropathy pain any time day or night. I am under the care of the VA gladly they provided me with the Micro-Z device with a Intelligent Textiles sock stimulation system from Prizm Medical. I have been wearing them since July 2015. They work 100% I do NOT get neuropathy pain anymore. I get a full night’s sleep no more 2:00 am hot needles pain in my feet. NO pain all day. I wear my stimulating compression socks for 8 hours every night. Prizm Medical has given me exceptional customer service and support. Their Micro-Z system works."

"The first day I tried it, I got up the next morning and there was dramatic improvement. The result is that I would not even consider surgery at this point. Most of the numbing is gone. All of the pain is gone...no discomfort in my foot at all."

"There is evidence that E-stim may impact on the healing of chronic wounds at a number of points in the healing process."

Antibacterial effects: Bacteria are a potent source of proinflammatory stimuli over a prolonged period, resulting in chronic inflammation and wound chronicity. For this reason, resolution of any bacterial imbalance is considered fundamental to the healing of chronic wounds (Schultz et al, 2003). Low-level E-stim has been shown in vitro to inhibit the growth of three organisms frequently isolated from chronic wounds — Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa (Kincaid and Lavoie, 1989).

Inflammation Modulation: Chronic inflammation needs to be resolved before functional granulation tissue is produced, and this process would be assisted by E-stim-driven recruitment of a normally functioning population of fresh macrophages (Moore, 1999).

Ordered Cellular Migration: Potential mode of action of E-stim on chronic wounds E-stim has been demonstrated to have potentially multiple effects on all phases of healing. One of the most marked cellular effects of E-stim demonstrated in the references cited above is the stimulation of directional cellular migration. This has particular therapeutic significance, as cell migration is required during each phase of healing.

In a meta-analysis of the effect of electrical stimulation on chronic wound healing, Gardner et al (1999) analysed the findings of 15 studies. Her conclusions state that, although further research is required to identify which E-stim devices are most effective, based on the average rates of healing E-stim increases the rate of chronic wound healing by 144%, thus inferring a positive effect on chronic wound healing.

This review evidences that electrical stimulation (ES) limits inflammation, increases wound blood perfusion, controls bacterial growth, increases fibroblast migration, induces angiogenesis, and encourages keratinocyte activity. This applies to both acute and chronic wounds. Additionally, electrical stimulation (notably pulsed current) significantly reduces the size of chronic wounds when compared to control groups with no ES.

Results from 22 well-designed randomized clinical trials and 10 high-quality SRs consistently support that EST can stimulate faster wound size reduction and/or produce a greater number of closed wounds compared to a group of similar patients receiving either standard wound care or sham EST.

Pooled results from well-conducted SRs provide strong support for the use of EST on various types of chronic wounds and pressure ulcers in particular.

These data show that treatment of muscle damage with Acustat electro-membrane microcurrent therapy reduces the severity of the symptoms. The mechanisms of action are unknown but are likely related to maintenance of intracellular Ca2 homeostasis after muscle damaging exercise.

"I started using the Silver-Thera™ Stocking at night and it has dramatically improved my balance and the sensation in my feet. I no longer feel like I'm walking on egg crates." The Silver-Thera™ Stocking did the trick for me!"

Microcurrent stimulation to the body causes radically increased roduction of ATP levels. This allows the body to perform whatever healing process it has undertaken in an accelerated fashion.